“Leaky gut” has become one of the most widely used—and widely misunderstood—terms in digestive health. Online, it is often presented as the hidden cause of everything from bloating and fatigue to autoimmune disease, skin problems, and brain fog. The proposed solutions may include restrictive diets, expensive food-sensitivity tests, herbal cleanses, probiotics, collagen powders, or long lists of supplements.

The scientific reality is more nuanced.

The intestinal barrier is real, and its permeability can increase under certain conditions. However, “leaky gut syndrome” is not a single, universally accepted medical diagnosis with one characteristic set of symptoms or one standard treatment. Increased intestinal permeability is better understood as a biological feature that can occur alongside conditions such as coeliac disease, inflammatory bowel disease, gastrointestinal infections, alcohol-related injury, and exposure to some medications.

This distinction matters because the most effective way to restore the intestinal barrier is usually not to chase permeability itself. It is to identify and address the factor that is disrupting the barrier while supporting the normal repair mechanisms of the gut.

What Is the Intestinal Barrier?

The lining of the digestive tract is not simply a passive wall. It is a highly regulated interface between the contents of the intestine and the rest of the body.

A healthy intestinal barrier must perform two apparently opposing tasks:

• absorb water, electrolytes, and nutrients;
• prevent excessive passage of microorganisms, toxins, antigens, and potentially harmful compounds.

Several layers contribute to this protection:

1. The gut microbiota, which competes with pathogens and produces metabolites that influence immune and epithelial function.
2. The mucus layer, which physically separates many intestinal microorganisms from epithelial cells.
3. The epithelial lining, formed by a single layer of tightly connected cells.
4. Tight junction proteins, which regulate movement between adjacent epithelial cells.
5. The intestinal immune system, which must respond to genuine threats without overreacting to food or harmless microorganisms.

Intestinal permeability is therefore not inherently abnormal. The barrier must remain selectively permeable. Problems arise when its regulation becomes disrupted and substances cross the lining in ways or quantities that promote inflammation or tissue injury.

A major clinical review published in Gut emphasizes that the intestinal barrier includes mucus, epithelial cells, tight junctions, immune defences, and microbial interactions—not just a single layer that is either “open” or “closed” (PubMed).

Can a Leaky Gut Heal?

The intestinal epithelium has a remarkable capacity for renewal. Under normal circumstances, epithelial cells are continually replaced, and the mucus layer is constantly regenerated.

This means that barrier dysfunction can improve, particularly when the underlying trigger is removed or treated. However, the phrase “heal a leaky gut” may be misleading when it suggests that one food, supplement, or short cleanse can permanently solve the problem.

Recovery depends on several factors:

• what caused the permeability change;
• whether there is active inflammation or tissue damage;
• whether nutrient deficiencies or malnutrition are present;
• whether the trigger is ongoing;
• whether an underlying disease requires medical treatment.

For example, intestinal damage caused by untreated coeliac disease will not be corrected simply by taking probiotics. The essential treatment is a strict gluten-free diet after an appropriate diagnosis. Similarly, inflammatory bowel disease may require anti-inflammatory, immunomodulatory, biological, or other medical therapy. Diet can support treatment, but it should not replace it.

For people interested in observing their digestive function more closely, it may also be helpful to learn how intestinal transit, elimination, and the condition of the gut barrier can be connected.

The central principle is simple: support the barrier, but treat the cause.

What Are the Possible Signs of Increased Intestinal Permeability?

There is no validated symptom checklist that can diagnose increased intestinal permeability.

Symptoms frequently attributed to “leaky gut” may include:

• bloating;
• abdominal discomfort;
• diarrhoea or constipation;
• excessive gas;
• food-related symptoms;
• fatigue;
• difficulty concentrating;
• skin complaints;
• joint discomfort.

These symptoms are real, but they are not specific to intestinal permeability. They can occur in irritable bowel syndrome, coeliac disease, inflammatory bowel disease, lactose intolerance, infections, thyroid disorders, anaemia, medication side effects, sleep deprivation, anxiety, and many other conditions.

Therefore, symptoms alone cannot establish that the intestinal barrier is damaged.

How Is Intestinal Permeability Measured?

In research, permeability is often investigated using orally administered probe molecules, such as lactulose and mannitol, followed by urine analysis. Different probes may be used to assess different regions of the digestive tract.

Other research methods include:

• analysis of intestinal biopsies;
• measurement of epithelial injury markers;
• examination of tight junction proteins;
• assessment of bacterial products or inflammatory markers;
• tests involving serum or faecal zonulin.

However, these methods are not interchangeable, and many are not standardized for routine diagnosis in otherwise healthy individuals.

Be cautious with commercial zonulin tests

Zonulin is frequently marketed as a direct measurement of “leaky gut,” but commercially available blood tests have important limitations. A human study found that serum zonulin measured by a commonly used enzyme-linked immunosorbent assay did not reliably reflect small-intestinal permeability measured with a sugar-absorption test (PubMed).

A single elevated zonulin result should therefore not be interpreted as proof that someone has a damaged intestinal barrier or needs an extensive supplement programme.

How to Support the Intestinal Barrier Naturally

1. Start by identifying the underlying cause

Before making major dietary changes, consider whether persistent symptoms could indicate an identifiable gastrointestinal condition.

Potential contributors include:

• coeliac disease;
• Crohn’s disease or ulcerative colitis;
• gastrointestinal infections;
• regular use of non-steroidal anti-inflammatory drugs;
• excessive alcohol consumption;
• severe or prolonged psychological or physical stress;
• undernutrition;
• food intolerances;
• irritable bowel syndrome;
• prolonged strenuous exercise, particularly in hot conditions.

A clinician may consider blood tests, coeliac serology, stool testing, inflammatory markers, faecal calprotectin, or endoscopic assessment depending on the symptoms.

This is far more informative than assuming that every digestive symptom is caused by a generic permeability problem.

2. Build meals around minimally processed foods

There is no single scientifically proven “leaky gut diet.” The strongest general approach is a nutritionally adequate dietary pattern based primarily on minimally processed foods.

A practical plate may include:

• vegetables or fruit;
• a source of protein;
• whole grains, legumes, potatoes, or another fibre-containing carbohydrate;
• olive oil, nuts, seeds, avocado, or another source of unsaturated fat.

A Mediterranean-style dietary pattern is especially relevant because it naturally combines vegetables, fruits, legumes, whole grains, nuts, seeds, olive oil, herbs, and moderate amounts of fish or other protein sources.

In a randomized clinical trial involving women with impaired intestinal barrier integrity, a Mediterranean dietary intervention was associated with favourable changes in barrier-related markers, partly mediated by short-chain fatty acids produced by intestinal bacteria (PubMed).

This does not prove that a Mediterranean diet cures every case of increased permeability. It does, however, support using an overall dietary pattern rather than relying on one supposedly therapeutic ingredient.

3. Increase fibre gradually

Dietary fibre supports gut health in several ways. Certain fibres are fermented by intestinal microorganisms, producing short-chain fatty acids such as acetate, propionate, and butyrate.

Butyrate is particularly important because it can:

• provide energy to colon cells;
• influence mucus production;
• regulate immune activity;
• support tight junction function;
• help maintain an environment that discourages some pathogens.

Human trials show that fibre interventions can change microbial composition and metabolism, although the response depends on the type of fibre and the individual (PubMed).

Useful sources include:

• oats and barley;
• beans, lentils, peas, and chickpeas;
• ground flaxseed and chia;
• vegetables;
• berries, apples, pears, and citrus fruits;
• nuts and seeds;
• whole grains;
• cooled potatoes, rice, or other sources of resistant starch.

Some people prefer to combine several complementary plant fibres rather than relying on a single source. A carefully balanced blend of psyllium, flax, chia, plantain seeds, and traditional botanical ingredients can provide different fibre fractions while supporting regular bowel movements and the natural removal of intestinal waste.

However, more fibre is not always better immediately. A rapid increase may cause gas, cramping, or diarrhoea, especially in people with irritable bowel syndrome or an already restricted diet.

Increase fibre gradually, drink sufficient fluid, and adjust the amount to your tolerance.

4. Eat a variety of plant foods

Different gut microorganisms use different carbohydrates and plant compounds. A repetitive diet may provide a narrow range of substrates, while a varied diet supplies multiple types of fibre, resistant starch, and polyphenols.

Instead of focusing on one “superfood,” rotate among:

• leafy and cruciferous vegetables;
• root vegetables;
• legumes;
• whole grains;
• berries and other fruits;
• nuts;
• seeds;
• herbs and spices.

Variety matters more than achieving a fashionable numerical target. Someone currently eating very few plant foods may benefit from introducing one or two new foods at a time rather than making a sudden, dramatic change.

5. Consider fermented foods if you tolerate them

Fermented foods may contain live microorganisms, fermentation products, or both. Examples include:

• yoghurt with live cultures;
• kefir;
• sauerkraut;
• kimchi;
• traditionally fermented vegetables;
• tempeh;
• miso.

In a randomized dietary study, a diet rich in fermented foods increased microbiome diversity and reduced several markers of inflammation. The study was relatively small, and it did not demonstrate that fermented foods directly “sealed” the intestinal barrier, but it provides clinically relevant evidence that they can influence the microbiome and immune system (PubMed).

Start with small portions. Fermented foods may aggravate symptoms in some people, particularly when they are high in salt, lactose, fermentable carbohydrates, or biogenic amines.

6. Use probiotics selectively rather than randomly

Probiotics are not a single treatment. Their effects depend on:

• the exact strain;
• the dose;
• the condition being treated;
• the duration of use;
• the existing microbiome;
• the outcome being measured.

A systematic review and meta-analysis of 26 randomized trials found that probiotics improved several markers related to barrier function and inflammation. However, the included populations, probiotic formulations, and testing methods varied considerably (PMC).

This means the evidence is promising but does not justify the claim that every probiotic product heals a leaky gut.

A reasonable approach is to:

1. define the symptom or condition being targeted;
2. choose a strain or formulation studied for that purpose;
3. use it for a defined trial period;
4. monitor the response;
5. stop if symptoms consistently worsen.

People who are severely immunocompromised, critically ill, or using central venous catheters should seek medical advice before using live microbial supplements.

7. Reduce alcohol exposure

Alcohol can directly affect epithelial cells, tight junction regulation, microbial composition, and immune signalling.

Human research has shown that ethanol can impair intestinal barrier function through cellular signalling pathways.

The relevant amount varies among individuals, but anyone experiencing persistent digestive symptoms may benefit from an alcohol-free period rather than merely switching between types of alcoholic drinks.

Alcohol should be considered especially carefully when symptoms coexist with liver disease, pancreatitis, gastritis, malnutrition, or medication use.

8. Review non-steroidal anti-inflammatory drug use

Non-steroidal anti-inflammatory drugs, or NSAIDs, include medicines such as ibuprofen, naproxen, diclofenac, and indomethacin.

These medications can damage the stomach and small intestine and may increase intestinal permeability. Research indicates that conventional NSAIDs can affect permeability even after relatively short exposure (PubMed).

Do not stop prescribed medication without medical advice. However, regularly using NSAIDs for headaches, muscle pain, or chronic discomfort should prompt a conversation with a doctor or pharmacist about:

• whether the medication is still necessary;
• whether the dose can be reduced;
• whether another treatment is more appropriate;
• whether gastrointestinal investigation is needed.

9. Reduce dependence on ultra-processed foods

Not every processed food is harmful, and food processing is not automatically a problem. Frozen vegetables, canned beans, natural yoghurt, and whole-grain bread are all processed to some degree.

The greater concern is a dietary pattern dominated by products that are often:

• low in intact fibre;
• high in refined starches or sugars;
• high in salt;
• energy dense;
• poor in plant diversity;
• easy to overconsume.

Research into specific additives and emulsifiers is still developing, and much mechanistic evidence comes from animal or laboratory models. Therefore, it is not scientifically justified to label every additive as a cause of intestinal permeability.

A more defensible recommendation is to make minimally processed foods the foundation of the diet while treating packaged products as supplementary rather than dominant.

Improving food quality can also support more predictable digestion and elimination—two important elements of a practical, gut-focused approach to natural cleansing and intestinal health.

10. Correct deficiencies instead of taking high doses “just in case”

The intestinal lining requires sufficient energy, protein, vitamins, minerals, and essential fatty acids for normal renewal.

Deficiencies in iron, vitamin B12, folate, vitamin D, zinc, or other nutrients may occur in people with restrictive diets, coeliac disease, inflammatory bowel disease, chronic diarrhoea, malabsorption, or poor appetite.

However, high-dose supplementation is not automatically beneficial. Excessive zinc, for example, can interfere with copper status, while unnecessary iron may cause gastrointestinal symptoms.

The safer principle is:

Test when appropriate, correct confirmed deficiencies, and maintain nutritional adequacy.

11. Do not remove gluten before coeliac testing

Gluten can cause intestinal inflammation and villous damage in people with coeliac disease. For these individuals, a strict lifelong gluten-free diet is medically necessary.

That does not mean gluten damages the intestinal barrier in everyone.

Starting a gluten-free diet before diagnostic testing can reduce coeliac antibodies and allow the intestinal lining to begin healing, potentially making the diagnosis more difficult. Clinical guidelines recommend completing the diagnostic process while the person is still consuming gluten (PubMed).

A gluten-free diet may also become low in fibre, iron, folate, and other nutrients when it relies heavily on refined gluten-free products.

12. Use low-FODMAP diets as temporary symptom-management tools

A low-FODMAP diet can reduce bloating, abdominal pain, and altered bowel habits in some people with irritable bowel syndrome.

However, it is not a universal “gut-healing” diet.

FODMAPs include fermentable carbohydrates found in many otherwise nutritious foods, including legumes, onions, garlic, wheat, some fruits, and certain dairy products. Long-term unnecessary restriction can reduce dietary variety and alter the abundance of some beneficial bacteria.

A low-FODMAP programme should ideally include three phases:

1. short-term restriction;
2. structured reintroduction;
3. long-term personalization.

The goal is to identify individual triggers while restoring the broadest diet possible. Research confirms that the diet can improve IBS symptoms, but it also affects the colonic microbiome, supporting the need for careful reintroduction.

13. Manage stress without claiming that all symptoms are psychological

The gut and brain communicate through neural, hormonal, immune, and microbial pathways. Stress can affect intestinal motility, pain sensitivity, secretion, eating behaviour, and immune function.

Laboratory and animal studies provide plausible mechanisms by which stress may influence permeability. Human evidence, however, is not completely consistent. A review of psychosocial stress and permeability in healthy people concluded that firm conclusions remain difficult because study methods and individual stress responses vary.

Stress management is still valuable, particularly when symptoms worsen during demanding periods.

Evidence-based options include:

• cognitive behavioural therapy;
• gut-directed hypnotherapy;
• mindfulness practice;
• breathing exercises;
• regular time outdoors;
• adequate recovery from work and exercise;
• treatment for anxiety or depression when needed.

This does not mean that digestive symptoms are imaginary. It means that the nervous system is one of the systems regulating gastrointestinal function.

14. Exercise regularly—but respect heat and recovery

Regular moderate physical activity can support metabolic health, bowel motility, stress regulation, and microbial diversity.

In contrast, prolonged strenuous exercise—especially in hot conditions—can temporarily reduce blood flow to the digestive tract and increase markers of epithelial injury and permeability. A systematic review found that gastrointestinal disturbance becomes more likely during prolonged exercise of significant intensity (PubMed).

Practical strategies include:

• building training volume gradually;
• staying appropriately hydrated;
• avoiding unfamiliar high-fat or high-fibre meals immediately before endurance exercise;
• allowing adequate recovery;
• reducing intensity during extreme heat;
• seeking assessment for recurrent exercise-related diarrhoea, bleeding, or severe abdominal pain.

15. Prioritize sleep and a regular daily rhythm

Sleep loss can affect appetite regulation, stress hormones, immune activity, glucose metabolism, and dietary choices.

Direct evidence that improving sleep alone repairs intestinal permeability is limited. Nevertheless, consistent sleep supports many systems involved in tissue repair and inflammatory regulation.

A useful target for most adults is a regular sleep schedule with enough time in bed to wake feeling adequately restored. Persistent insomnia, loud snoring, witnessed pauses in breathing, or severe daytime sleepiness should be medically assessed.

Which “Gut-Healing” Supplements Have the Best Evidence?

No supplement has been proven to repair intestinal permeability in every person.

L-glutamine

Glutamine is an important fuel for intestinal and immune cells. Supplementation has been studied in critical illness, exercise, infections, irritable bowel syndrome, and other conditions.

Results are mixed and highly dependent on the population, dose, and clinical context. Evidence from one condition should not automatically be generalized to otherwise healthy people with nonspecific symptoms.

Zinc and zinc carnosine

Zinc participates in epithelial repair and immune function. Zinc carnosine has been investigated for gastrointestinal mucosal protection, but it is not an established universal treatment for increased intestinal permeability.

Long-term high-dose zinc can cause copper deficiency.

Collagen and bone broth

Collagen provides amino acids, but there is little direct clinical evidence that collagen powders or bone broth restore intestinal permeability in humans.

They can be included as foods if desired, but they should not replace a varied diet or medical treatment.

Butyrate supplements

Butyrate is biologically important, but taking a butyrate supplement is not necessarily equivalent to producing short-chain fatty acids through microbial fermentation of dietary fibre.

Clinical effects depend on delivery, dose, formulation, and the condition being studied.

Herbal antimicrobials and “parasite cleanses”

Broad antimicrobial products may cause side effects, interact with medication, and disrupt microbial communities. They should not be used simply because bloating or fatigue is assumed to represent yeast, parasites, or “bad bacteria.”

Suspected infections should be tested and treated appropriately.

A Practical Four-Week Gut-Support Plan

This plan is not a substitute for treatment of coeliac disease, inflammatory bowel disease, infection, or another diagnosed condition.

Week 1: Establish the baseline

• Record meals, symptoms, bowel habits, sleep, alcohol, medications, and stress.
• Avoid starting several supplements at once.
• Reduce alcohol.
• Review frequent NSAID use with a healthcare professional.
• Build regular meal times where possible.

Week 2: Improve food quality

• Add vegetables or fruit to at least two meals per day.
• Replace one refined grain with a whole-grain option.
• Include a tolerable source of protein at each main meal.
• Use olive oil, nuts, seeds, or avocado instead of relying mainly on highly processed fats.
• Reduce foods that repeatedly displace more nutritious meals.

Week 3: Expand fibre and diversity

• Introduce one new legume, whole grain, vegetable, fruit, nut, or seed.
• Increase fibre gradually rather than abruptly.
• When convenience matters, consider a multi-source plant fibre formula designed to support regularity, digestive comfort, and daily intestinal cleansing, introducing it gradually and adjusting the serving to individual tolerance.
• Include resistant-starch foods if tolerated.
• Consider a small portion of a fermented food.
• Maintain sufficient fluid intake.

Week 4: Personalize

Review the symptom record and ask:

• Which changes clearly helped?
• Which foods caused consistent, reproducible symptoms?
• Were symptoms related to portion size rather than the food itself?
• Did sleep, alcohol, medication, stress, or exercise intensity matter?
• Are symptoms persistent enough to require medical evaluation?

The aim is not to create the most restrictive diet possible. It is to identify a varied, nutritionally adequate pattern that produces the fewest symptoms.

When Should You See a Doctor?

Seek medical assessment rather than relying on a “leaky gut protocol” if you experience:

• blood in the stool;
• black or tar-like stool;
• unexplained weight loss;
• persistent fever;
• anaemia;
• repeated vomiting;
• severe or worsening abdominal pain;
• diarrhoea that persists;
• bowel symptoms that repeatedly wake you at night;
• difficulty swallowing;
• signs of dehydration;
• a strong family history of coeliac disease, inflammatory bowel disease, or colorectal cancer.

Urgent care may be required for severe pain, heavy bleeding, fainting, confusion, inability to keep fluids down, or signs of significant dehydration.

Frequently Asked Questions

How long does it take to heal a leaky gut?

There is no universal timeline. Temporary permeability changes caused by alcohol, medication, infection, or strenuous exercise may improve after the trigger is removed. Recovery from coeliac disease or inflammatory bowel disease may take much longer and depends on disease control, nutritional status, age, and adherence to treatment.

What is the fastest way to repair the intestinal lining?

There is no scientifically proven rapid repair method. The most effective strategy is to identify the cause, remove ongoing irritants when possible, maintain adequate nutrition, and treat any underlying disease.

Are eggs, dairy, or grains bad for a leaky gut?

Not universally. These foods should not be eliminated unless they cause reproducible symptoms, an allergy or intolerance has been established, or a clinician has recommended restriction for a specific reason.

Does fasting heal the intestinal barrier?

Fasting changes digestive activity and microbial metabolism, but there is insufficient evidence that prolonged fasting is a general treatment for increased intestinal permeability. Aggressive fasting may worsen undernutrition, disordered eating, weakness, or nutrient deficiencies.

Can probiotics make symptoms worse?

Yes. Some people experience increased gas, bloating, altered bowel movements, or abdominal discomfort. Effects are product- and strain-specific. Stop the product and seek advice if symptoms are severe or persistent.

Is leaky gut the cause of autoimmune disease?

Altered barrier function has been studied in several autoimmune conditions, but association does not prove that permeability is the sole cause. Genetics, immune regulation, environmental exposures, infections, microbiota, and disease-specific mechanisms may all contribute.

The Bottom Line

The intestinal barrier is a real and complex biological system, but “leaky gut” should not become a catch-all explanation for every digestive or systemic symptom.

A credible natural strategy focuses on fundamentals:

• investigate persistent symptoms;
• treat the underlying condition;
• eat a varied, minimally processed diet;
• increase fibre gradually;
• include fermented foods when tolerated;
• limit alcohol;
• review unnecessary NSAID use;
• correct genuine nutrient deficiencies;
• avoid unnecessary restrictive diets;
• manage stress, sleep, and exercise recovery;
• use probiotics and supplements selectively.

The goal is not to “seal” the intestine completely. A healthy gut must remain selectively permeable. The real objective is to restore appropriate barrier regulation while supporting digestion, nutrition, microbial balance, and immune function.

References

1. Camilleri M. Leaky gut: mechanisms, measurement and clinical implications in humans. Gut. 2019;68(8):1516–1526. doi:10.1136/gutjnl-2019-318427. PubMed
2. Nascimento DSM, Mota ACCC, Carvalho MCC, et al. Can Diet Alter the Intestinal Barrier Permeability in Healthy People? A Systematic Review. Nutrients. 2024;16(12):1871. doi:10.3390/nu16121871. PMC
3. Seethaler B, Nguyen NK, Basrai M, et al. Short-chain fatty acids are key mediators of the favorable effects of the Mediterranean diet on intestinal barrier integrity: data from the randomized controlled LIBRE trial. American Journal of Clinical Nutrition. 2022;116(4):928–942. doi:10.1093/ajcn/nqac175. PubMed
4. Kimble R, Gouinguenet P, Ashor A, et al. Effects of a Mediterranean diet on the gut microbiota and microbial metabolites: a systematic review of randomized controlled trials and observational studies. Critical Reviews in Food Science and Nutrition. 2023;63(27):8698–8719. doi:10.1080/10408398.2022.2057416. PubMed
5. Zheng Y, Zhang Z, Tang P, et al. Probiotics fortify intestinal barrier function: a systematic review and meta-analysis of randomized trials. Frontiers in Immunology. 2023;14:1143548. doi:10.3389/fimmu.2023.1143548. PMC
6. Wastyk HC, Fragiadakis GK, Perelman D, et al. Gut-microbiota-targeted diets modulate human immune status. Cell. 2021;184(16):4137–4153.e14. doi:10.1016/j.cell.2021.06.019. PubMed
7. So D, Whelan K, Rossi M, et al. Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis. American Journal of Clinical Nutrition. 2018;107(6):965–983. PubMed
8. Tatucu-Babet OA, Forsyth A, Owen E, et al. Serum zonulin measured by enzyme-linked immunosorbent assay may not be a reliable marker of small intestinal permeability in healthy adults. Nutrition Research. 2020;78:82–92. doi:10.1016/j.nutres.2020.05.003. PubMed
9. La Torre D, Van Oudenhove L, Vanuytsel T, Verbeke K. Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence? Neurobiology of Stress. 2023;24:100579. doi:10.1016/j.ynstr.2023.100579. PMC
10. Bjarnason I, Takeuchi K. Intestinal permeability in the pathogenesis of NSAID-induced enteropathy. Journal of Gastroenterology. 2009;44(Suppl 19):23–29. PubMed
11. Elamin E, Masclee A, Troost F, et al. Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach. PLoS ONE. 2014;9(9):e107421. PubMed
12. Costa RJS, Snipe RMJ, Kitic CM, Gibson PR. Systematic review: exercise-induced gastrointestinal syndrome—implications for health and intestinal disease. Alimentary Pharmacology & Therapeutics. 2017;46(3):246–265. PubMed
13. Effects of a low FODMAP diet on the colonic microbiome in irritable bowel syndrome: a systematic review with meta-analysis. American Journal of Clinical Nutrition. 2022. PubMed
14. Al-Toma A, Volta U, Auricchio R, et al. European Society for the Study of Coeliac Disease guideline for coeliac disease and other gluten-related disorders. United European Gastroenterology Journal. 2019;7(5):583–613. PubMed
15. Drabińska N, Krupa-Kozak U, Jarocka-Cyrta E. Limited support for a direct connection between prebiotics and intestinal permeability—a systematic review. International Journal of Food Sciences and Nutrition. 2024;75:323–342. PMC